ASSESSING THE APPROPRIATENESS OF STRESSI NDUCED ULCER PROPHYLAXIS FOR HOSPITALIZED PATIENTS

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Authors

  • Khaled Al-Akhali Department of Pharmacy, Medical school in Thamar University, Republic of Yemen & Lebanese International University, School of Pharmacy, Department of Biomedical Sciences, Republic of Yemen
  • Ali Salman Al-Shami Department of Pharmacy, Medical school in Thamar University, Republic of Yemen
  • Abdullah Ahmed Al-dahbali Lebanese International University, School of Pharmacy, Department of Biomedical Sciences, Republic of Yemen & Department of Clinical Pharmacy, College of Pharmacy in Sanaa University, Republic of Yemen
  • Sakran Faiz Khaled Mohammed Lebanese International University, School of Pharmacy, Department of Biomedical Sciences, Republic of Yemen
https://doi.org/10.55559/jjbrpac.v1i3.365

Keywords:

stress induces ulcer prophylaxis, medication, proton pump inhibitors, histamine2 antagonists, hospitalized patients

Abstract

Purpose: This study's objective was to explore assessing the appropriateness of stress-induced ulcer prophylaxis for hospitalized patients.

Patients and methods: A cross-sectional study were conducted for 3 months among hospitalized patients at AL-Kuwait Hospital in Sana’a, Yemen.

Results: Among all the study participants, nearly 17 (14%) out of 120 patients were approved for stress-induced ulcer prophylaxis in the past 3 months. 42 (35%) of the patients in our study were never candidates for a stress-induced ulcer prophylaxis regimen, neither globally nor locally, where controversy around disapproval globally and approval locally and vice versa was present in 61 (51%) patients. The most common indication for proton pump inhibitors was stress-induced ulcers, followed by gastric ulcers, duodenal ulcers, and people receiving glucocorticoids and NSAIDs in certain amounts. PPI use was significantly more prevalent among hospitalized patients, followed by outpatients.

Conclusions: Stress-induced ulcer prophylaxis as well as not following up with the global protocols were common among hospitalized patients. pieces of advice are recommended in this situation.

References

DiPiro J, Yee G, Posey M, Haines S, Nolin T, Ellingrod V. PHARMACOTHERAPY: a pathophysiologic approach, eleventh edition. S.L.: Mcgraw-Hill Education; 2020.

Sharkey KA, MacNaughton KW. Chapter 49: Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease. In: pharmacological basis of therapeutics. New York: McGraw-Hill Education; 2006.

Tryba M, Cook D. Current Guidelines on Stress Ulcer Prophylaxis. Drugs. 1997 Oct;54(4):581–96. https://doi.org/10.2165/00003495-199754040-00005 DOI: https://doi.org/10.2165/00003495-199754040-00005

Batuwitage BT, Kingham JGC, Morgan NE, Bartlett RL. Inappropriate prescribing of proton pump inhibitors in primary care. Postgraduate Medical Journal. 2007 Jan 1;83(975):66–8. https://doi.org/10.1136/pgmj.2006.051151 DOI: https://doi.org/10.1136/pgmj.2006.051151

ASHP Therapeutic Guidelines on Stress Ulcer Prophylaxis. American Journal of Health-System Pharmacy. 1999 Feb 15;56(4):347–79. https://doi.org/10.1093/ajhp/56.4.347 DOI: https://doi.org/10.1093/ajhp/56.4.347

Scagliarini R, Magnani E, Praticò A, Bocchini R, Sambo P, Pazzi P. Inadequate Use of Acid-Suppressive Therapy in Hospitalized Patients and Its Implications for General Practice. Digestive Diseases and Sciences. 2005 Dec;50(12):2307–11. https://doi.org/10.1007/s10620-005-3052-4 DOI: https://doi.org/10.1007/s10620-005-3052-4

Alakhali KM, Bayoumi HM, Abunakhaa ES, Ahmed M, Alqahtani NS, Jaber RA, et al. Evaluación de la prescripción y uso de medicamentos supresores de ácido en hospitales centrales en la región de Abha, Arabia Saudita. Ars Pharmaceutica (Internet). 2019 Jun 6;60(2). https://doi.org/10.30827/ars.v60i2.8687 DOI: https://doi.org/10.30827/ars.v60i2.8687

Blume H, Donath F, Warnke A, Schug BS. Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors. Drug Safety. 2006;29(9):769–84. https://doi.org/10.2165/00002018-200629090-00002

Bashford JNR, Norwood J, Chapman SR. Why are patients prescribed proton pump inhibitors? Retrospective analysis of link between morbidity and prescribing in the General Practice Research Database. BMJ. 1998 Aug 15;317(7156):452–6. https://doi.org/10.1136/bmj.317.7156.452 DOI: https://doi.org/10.1136/bmj.317.7156.452

Abdallah Damin Abukhalil, Abu OA, Saad A, Falana H, Ni'meh Al-Shami, Naseef H, et al. Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study. International Journal of General Medicine. 2023 Jan 1;Volume 16:141–50. https://doi.org/10.2147/IJGM.S396202 DOI: https://doi.org/10.2147/IJGM.S396202

Sebastian S, Kernan N, Qasim A, O’Morain C, Buckley M. Appropriateness of gastric antisecretory therapy in hospital practice. Irish Journal of Medical Science. 2003 Jul;172(3):115–7. https://doi.org/10.1007/BF02914494 DOI: https://doi.org/10.1007/BF02914494

Molloy D, Molloy A, O’Loughlin C, Falconer M, Hennessy M. Inappropriate use of proton pump inhibitors. Irish Journal of Medical Science. 2009 Sep 11;179(1):73–5. https://doi.org/10.1007/s11845-009-0426-1 DOI: https://doi.org/10.1007/s11845-009-0426-1

Blume H, Donath F, Warnke A, Schug BS. Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors. Drug Safety. 2006;29(9):769–84. https://doi.org/10.2165/00002018-200629090-00002 DOI: https://doi.org/10.2165/00002018-200629090-00002

Zalloum N, Farha RA, Awwad O, Samara N. Inappropriate prescribing of proton pump inhibitors among patients in two Jordanian tertiary health facilities. Tropical Journal of Pharmaceutical Research. 2016 Dec 7;15(11):2489. https://doi.org/10.4314/tjpr.v15i11.26 DOI: https://doi.org/10.4314/tjpr.v15i11.26

Eid SM, Boueiz A, Paranji S, Mativo C, BA RL, Abougergi MS. Patterns and Predictors of Proton Pump Inhibitor Overuse among Academic and Non-Academic Hospitalists. Internal Medicine. 2010;49(23):2561–8. https://doi.org/10.2169/internalmedicine.49.4064 DOI: https://doi.org/10.2169/internalmedicine.49.4064

Published on: 2024-06-29

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How to Cite

Al-Akhali , K., Al-Shami, A. S., Al-dahbali, A. A., & Mohammed, S. F. K. (2024). ASSESSING THE APPROPRIATENESS OF STRESSI NDUCED ULCER PROPHYLAXIS FOR HOSPITALIZED PATIENTS. Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry, 1(3), 16–20. https://doi.org/10.55559/jjbrpac.v1i3.365

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Research Article
2584-2536