Nanoparticles in Drug Delivery Systems: Challenges, Innovations, and Surface Modification for Targeted Therapeutics
Keywords:
Nanoparticles, Drug delivery systems, Targeted therapeutics, Biocompatibility, Surface modification, Stimuli-responsive systems, NanomedicineAbstract
Nanoparticle based drug transport structures have revolutionized the field of therapeutics via offering several benefits, together with better solubility, bioavailability, targeted transport, and managed release. These structures can encapsulate an extensive variety of healing agents, from small molecules to huge biomolecules together with proteins and nucleic acids, making them flexible gear in present day remedy. But, the scientific translation of nanoparticle based drug transport structures faces tremendous demanding situations, together with biocompatibility, toxicity, balance, scalability, and reproducibility. This text targets to offer a complete review of the key problems impeding the large use of nanoparticles in drug transport. We are able to talk revolutionary strategies, together with stimuli responsive structures, ligand conjugation for energetic concentrated on and surface modification techniques that address these demanding situations. Furthermore, the destiny of nanoparticle-based therapeutics is explored, that specialize in their integration into customized remedy and theranostic packages. Subsequently, we are able to take a look at the regulatory and manufacturing hurdles that must be triumph over to recognise the overall capacity of nanoparticle drug transport structures.
References
Zhang, Y., et al. (2020). Biocompatibility and toxicity of nanoparticles: A review. Frontiers in Pharmacology, 11, 587877. https://doi.org/10.3389/fphar.2020.587877
Wei, Y., et al. (2021). PEGylation of nanoparticles for drug delivery: Strategies and applications. Materials Science and Engineering: C, 118, 111531. https://doi.org/10.1016/j.msec.2020.111531
Lee, S., et al. (2021). PEGylated nanoparticles in drug delivery: Current status and future perspectives. Journal of Controlled Release, 329, 256–272. https://doi.org/10.1016/j.jconrel.2020.09.038
Mahmoud, S., et al. (2021). Zwitterionic nanoparticles for nanomedicine applications. Nature Nanotechnology, 16, 139–153. https://doi.org/10.1038/s41565-020-00794-y
Kim, S., et al. (2019). Active targeting of nanoparticles in drug delivery: A review. Nano Today, 26, 8–29. https://doi.org/10.1016/j.nantod.2019.04.008
Shi, J., et al. (2020). Stimuli-responsive drug delivery systems: Strategies and applications. Advanced Drug Delivery Reviews, 153, 1–13. https://doi.org/10.1016/j.addr.2020.05.002
Pan, Y., et al. (2020). Regulatory considerations for nanoparticle-based drug delivery systems. Regulatory Toxicology and Pharmacology, 112, 104582. https://doi.org/10.1016/j.yrtph.2020.104582
Liu, W., et al. (2021). pH-responsive nanoparticles for drug delivery applications: A review. Journal of Drug Delivery Science and Technology, 61, 102143. https://doi.org/10.1016/j.jddst.2020.102143
Zhang, Y., et al. (2020). Redox-responsive nanoparticles for targeted drug delivery in cancer therapy. Advanced Drug Delivery Reviews, 156, 18–38. https://doi.org/10.1016/j.addr.2020.07.003
Sokolova, V., et al. (2020). Thermosensitive nanoparticles for drug delivery. Journal of Nanobiotechnology, 18, 52. https://doi.org/10.1186/s12951-020-00607-7
Zhang, Z., et al. (2021). Active targeting strategies for nanoparticle-based drug delivery systems. International Journal of Nanomedicine, 16, 1459–1473. https://doi.org/10.2147/IJN.S295807
Patil, M., et al. (2019). Strategies for improving the stability of PEGylated nanoparticles. Nanomedicine, 14(5), 621–634. https://doi.org/10.2217/nnm-2018-0410
Wei, J., et al. (2021). Zwitterionic polymers for nanomedicine applications. Nature Communications, 12, 1039. https://doi.org/10.1038/s41467-021-21305-5
Zhang, Q., et al. (2021). Biomimetic nanoparticles for drug delivery: A review. Biomaterials, 275, 120916. https://doi.org/10.1016/j.biomaterials.2021.120916
