Phthalein Dyes: Chemistry and Characteristics


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Dyes, Phthalein dyes, pH indicator, Phenolphthalein, toxicity


Phthalein dyes, a distinguished class of synthetic organic compounds, have garnered recognition for their multifaceted utility as both pH indicators and coloring agents in a wide array of industrial and laboratory contexts. This comprehensive review endeavors to delve into the nuanced chemistry and defining attributes of phthalein dyes, providing insights into their structural intricacies and expansive applications. Furthermore, the review expounds upon the paramount significance of phthalein dyes across diverse domains, elucidating their foundational chemistry and versatile properties that underpin their indispensable role in contemporary scientific and industrial pursuits. Moreover, in light of growing concerns about their toxicity and associated health implications, this review advocates for the exploration and adoption of safer alternatives, thereby emphasizing the imperative for continued research and innovation in this domain.


Hassanien, R., Hassan, Z.A., Al-Assy, W. and Ibrahim, S.M., 2022. Removal of toxic thymol sulfone phthalein dye from wastewater by using efficient adsorbent NiO nanoparticles. Journal of Molecular Structure, 1269, p.133864.

Jasińska, A., Góralczyk-Bińkowska, A., Soboń, A. and Długoński, J., 2019. Lignocellulose resources for the Myrothecium roridum laccase production and their integrated application for dyes removal. International Journal of Environmental Science and Technology, 16, pp.4811-4822.

Khan, S.A., Alam, S.D., Bagadi, M., Anjum, R. and Yusuf, M., 2024. Chromatographic Separation of Antihistamine Drugs using HPLC. Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry, 1(2), 22-27.

Rahmat, M., Kiran, S., Gulzar, T., Yusuf, M., Nawaz, R., Khalid, J., Fatima, N., Ullah, A. and Azam, M., 2023. Plant-assisted synthesis and characterization of MnO2 nanoparticles for removal of crystal violet dye: an environmental remedial approach. Environmental Science and Pollution Research, 30(20), pp.57587-57598.

Sabnis, R.W., 2018. Developments in the chemistry and applications of phthalein dyes. Part 1: Industrial applications. Coloration Technology, 134(3), 187-205.

Yeow, P.K., Wong, S.W. and Hadibarata, T., 2021. Removal of azo and anthraquinone dye by plant biomass as adsorbent–a review. Biointerface Res. Appl. Chem, 11, pp.8218-8232.

Yusuf, M., Ahmad, A., Shahid, M., Khan, M.I., Khan, S.A., Manzoor, N. and Mohammad, F., 2012. Assessment of colorimetric, antibacterial and antifungal properties of woollen yarn dyed with the extract of the leaves of henna (Lawsonia inermis). Journal of cleaner production, 27, pp.42-50.

Yusuf, M., Shahid, M., Khan, M.I., Khan, S.A., Khan, M.A. and Mohammad, F., 2015. Dyeing studies with henna and madder: A research on effect of tin (II) chloride mordant. Journal of Saudi Chemical Society, 19(1), pp.64-72.

Yusuf, M., Shabbir, M., & Mohammad, F. (2017). Natural colorants: Historical, processing and sustainable prospects. Natural Products and Bioprospecting, 7, 123-145.

Yusuf, M. ed., 2018. Handbook of textile effluent remediation. Jenny Stanford Publishing: US.

Yusuf, M., 2019. Synthetic dyes: a threat to the environment and water ecosystem. In: Textiles and clothing, Shabbir, M. (ed.) Scrivener Publishing LLC: Beverly, pp.11-26.

Yusuf, M., Sharma, S., Khan, S.A., Prasad, L. (2023a). Current applications of biomolecules as anticoronavirus drugs. In: Handbook of Biomolecules: Fundamentals, Properties and Applications, Elsevier, USA, pp. 355-369.

Yusuf, M., Pal, S., Shahid, M., Asif, M., Khan, S.A., Tyagi, R. (2023b). Docking and ADMET Study of ArTurmerone: Emerging Scaffold for Acetylcholine Esterase Inhibition and Antidiabetic Target. J. Appl. Organometallic Chem., 3(1), 1-11.

Yusuf, M. (2023). Insights into the in-silico research: Current scenario, advantages, limits, and future perspectives. Life in Silico, 1(1), 13-25.

Yusuf, M., Haji, A. eds. (2023). Handbook of Nanofibers and Nanocomposites Characteristics, Synthesis, and Applications in Textiles, Jenny Stanford Publishing: US.

Published on: 2024-03-20

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Yusuf, M. (2024). Phthalein Dyes: Chemistry and Characteristics. Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry, 1(3), 01–05.



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