Chromatographic Separation of Antihistamine Drugs using HPLC

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Authors

  • Shafat Ahmad Khan Department of Chemistry, School of Basic Sciences, Galgotias University, Greater Noida, U.P. 201310 India https://orcid.org/0000-0003-3744-6391
  • Syed Dilshad Alam Analytical Research & Development, Jubilant Biosys Limited, Knowledge Park- II, Greater Noida, Uttar Pradesh 201310 India https://orcid.org/0000-0001-9907-8665
  • Muralidhararao Bagadi Analytical Research & Development, Jubilant Biosys Limited, Knowledge Park- II, Greater Noida, Uttar Pradesh 201310 India https://orcid.org/0000-0002-4428-4127
  • Rushda Anjum Department of Chemistry, School of Basic Sciences, Galgotias University, Greater Noida, U.P. 201310 India
  • Mohd Yusuf Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh 247121 India https://orcid.org/0000-0003-0927-8490
https://doi.org/10.55559/jjbrpac.v1i2.252

Keywords:

Antihistamines, Allergic response, Separation, HPLC

Abstract

The chromatographic separation of antihistamine drugs using High-Performance Liquid Chromatography (HPLC) has garnered significant attention due to its pivotal role in pharmaceutical analysis. Antihistamines, vital in managing allergic disorders, present complex challenges in terms of analytical assessment owing to their diverse chemical structures and stereochemistry. This review aims to provide an overview of one of the best methodologies employed in HPLC-based separation of antihistamine drugs. Emphasis is placed on the separation of both nonracemic and racemic forms, considering their distinct pharmacological profiles and therapeutic implications. Various aspects, including method development, optimization strategies, column selection, and detection techniques, are scrutinized to highlight the crucial parameters influencing separation efficiency and accuracy. Furthermore, the review delves into the application of chiral HPLC methods for resolving enantiomeric mixtures of antihistamines, underscoring their importance in pharmaceutical research and development. By synthesizing recent literature findings and methodological advancements, this review offers insights into the current state-of-the-art in HPLC-based separation of antihistamine drugs and outlines future directions for research in this critical field.

References

Ali, I., Al‐Othman, Z. A., Al‐Warthan, A., Alam, S. D., & Farooqi, J. A. (2014). Enantiomeric separation and simulation studies of pheniramine, Oxybutynin, Cetirizine, and brinzolamide chiral drugs on amylose-based columns, Chirality, 26(3), 136–143. https://doi.org/10.1002/chir.22276 DOI: https://doi.org/10.1002/chir.22276

Ali, I., Raja, R., Alam, S.D., Shirsath, V., Jain, A.K., Locatelli, M. David, V. (2021). A comparison of chiral separations by supercritical fluid chromatography and high-performance liquid chromatography. Journal of Liquid Chromatography & Related Technologies, 44, (11-12), 450-463. https://doi.org/10.1080/10826076.2021.1979037 DOI: https://doi.org/10.1080/10826076.2021.1979037

Ali, I., Alam, S.D., Raja, R., Shirsath, V., Jain, A.K., Yusuf, K., Aljuwayid, A.M., Sillanpää, M. (2022). Chiral separation of β-blockers by supercritical fluid chromatography using Chiralpak-IG and Chiralpak IBN-5 columns. Chirality, 34(6), 848-855. https://doi.org/10.1002/chir.23440 DOI: https://doi.org/10.1002/chir.23440

Ali, I., Alam, S. D., Raja, R., Khan, S. A., Anjum, R., Jain, A. K., Locatelli, M. (2023). Advances in Simple and Chiral-HPLC Methods for Antiallergic Drugs and Chiral Recognition Mechanism. Analytica, 4(1), 66-83.). https://doi.org/10.3390/analytica4010007 DOI: https://doi.org/10.3390/analytica4010007

Asif, M., Yusuf, M., Almehmadi, Alsaiari, AA, Allahyani, M., Aljuaid M. and Alsharif, A (2024). Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica as Competent Natural Molecules to Treat COVID-19 Virus Variant. Letters in Organic Chemistry, 21(5), 466-477. https://doi.org/10.2174/0115701786263427231123103651 DOI: https://doi.org/10.2174/0115701786263427231123103651

da Costa, L. M., Oliveira de Almeida Leite, H., Kassab, N. M., & Singh, A. K. (2019). Green analytical methods for the separation of seven antihistamines: Application in separation of azelastine and related impurities in nasal solution. International Journal of Analytical Chemistry, 2019(9489723), 1-11. https://doi.org/10.1155/2019/9489723 DOI: https://doi.org/10.1155/2019/9489723

Hu, Y. P., Song, Y. R., Wang, D. F., Yang, Y. P., Hou, D. Y., & Ouyang, J. (2004). Study on enantiomeric separation of cetirizine on HPLC with a chiral ovomucoid column, Chinese Journal of Pharmaceutical Analysis, 24(3), 289–293.

Kang, S. W., Jang, H. J., Moore, V. S., Park, J. Y., Kim, K. A., Youm, J. R., & Han, S. B. (2010). Enantioselective determination of cetirizine in human plasma by normal-phase liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry. Journal of Chromatography B, 878(32), 3351-3357. https://doi.org/10.1016/j.jchromb.2010.10.019 DOI: https://doi.org/10.1016/j.jchromb.2010.10.019

Lim, C.K. and Lord, G. (2002). Current developments in LC-MS for Pharmaceutical Analysis, Biological & Pharmaceutical Bulletin, 25(5), 547–557. https://doi.org/10.1248/bpb.25.547 DOI: https://doi.org/10.1248/bpb.25.547

Raja, R., Alam, SD, Srisath, V., Jain, A.K., ALOthman, Z.A., Mohammed, A.AA. Mohammad, Islam, A., Bhatt, T. and Ali, I. (2021). A comparative study of chiral separation of proton pump inhibitors by supercritical fluid chromatography and high-performance liquid chromatography. Journal of Separation Science, 1–8. https://doi.org/10.1002/jssc.202100834 DOI: https://doi.org/10.1002/jssc.202100834

Shasho, H., Sakur, A.A. and Trefi, S. (2018). Separation and assay of four antihista-mine drugs diphenhydramine, chlorpheniramine, Cyproheptadine and Fexofenadine in pharmaceutical forms by a single HPLC method, International Journal of Pharmacy and Pharmaceutical Sciences, 10(4), 53-62. https://doi.org/10.22159/ijpps.2018v10i4.24819 DOI: https://doi.org/10.22159/ijpps.2018v10i4.24819

Simon, F.E. and Simons, K.J. (2008). H1 antihistamines: Current status and future directions, World Allergy Organization Journal, 1(9), 145–155. https://doi.org/10.1186/1939-4551-1-9-145 DOI: https://doi.org/10.1186/1939-4551-1-9-145

Tao, Q.F., Zhu, X.P. and Zhao, Y. (2007). Chiral resolution of cetirizine by capillary electrochromatography using norvancomycin hydrochloride as chiral selector,” Chinese Journal of Pharmaceutical Analysis, 27(5), pp. 686–688.

Xiong, X., Wang, K., Tang, T., Fang, J., & Chen, Y. (2021). Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers, Scientific Reports, 11(1), 1-18. https://doi.org/10.1038/s41598-021-87511-5 DOI: https://doi.org/10.1038/s41598-021-87511-5

Yusuf, M. (2023). Insights into the in-silico research: Current scenario, advantages, limits, and future perspectives. Life In Silico, 1(1), 13-25. https://life-insilico.com/index.php/pub/article/view/5

Zhou, J., Luo, P., Chen, S., Meng, L., Sun, C., Du, Q., & Sun, F. (2016). Enantioseparation of six antihistamines with immobilized cellulose chiral stationary phase by HPLC. Journal of chromatographic science, 54(4), 531-535. https://doi.org/10.1093/chromsci/bmv177 DOI: https://doi.org/10.1093/chromsci/bmv177

Published on: 25-04-2024

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How to Cite

Khan, S. A., Alam, S. D., Bagadi, M., Anjum, R., & Yusuf, M. (2024). Chromatographic Separation of Antihistamine Drugs using HPLC. Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry, 1(2), 22–27. https://doi.org/10.55559/jjbrpac.v1i2.252

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Research Article
2584-2536