Chromatographic Separation of Antihistamine Drugs using HPLC
Keywords:
Antihistamines, Allergic response, Separation, HPLCAbstract
The chromatographic separation of antihistamine drugs using High-Performance Liquid Chromatography (HPLC) has garnered significant attention due to its pivotal role in pharmaceutical analysis. Antihistamines, vital in managing allergic disorders, present complex challenges in terms of analytical assessment owing to their diverse chemical structures and stereochemistry. This review aims to provide an overview of one of the best methodologies employed in HPLC-based separation of antihistamine drugs. Emphasis is placed on the separation of both nonracemic and racemic forms, considering their distinct pharmacological profiles and therapeutic implications. Various aspects, including method development, optimization strategies, column selection, and detection techniques, are scrutinized to highlight the crucial parameters influencing separation efficiency and accuracy. Furthermore, the review delves into the application of chiral HPLC methods for resolving enantiomeric mixtures of antihistamines, underscoring their importance in pharmaceutical research and development. By synthesizing recent literature findings and methodological advancements, this review offers insights into the current state-of-the-art in HPLC-based separation of antihistamine drugs and outlines future directions for research in this critical field.
References
Ali, I., Al‐Othman, Z. A., Al‐Warthan, A., Alam, S. D., & Farooqi, J. A. (2014). Enantiomeric separation and simulation studies of pheniramine, Oxybutynin, Cetirizine, and brinzolamide chiral drugs on amylose-based columns, Chirality, 26(3), 136–143. https://doi.org/10.1002/chir.22276 DOI: https://doi.org/10.1002/chir.22276
Ali, I., Raja, R., Alam, S.D., Shirsath, V., Jain, A.K., Locatelli, M. David, V. (2021). A comparison of chiral separations by supercritical fluid chromatography and high-performance liquid chromatography. Journal of Liquid Chromatography & Related Technologies, 44, (11-12), 450-463. https://doi.org/10.1080/10826076.2021.1979037 DOI: https://doi.org/10.1080/10826076.2021.1979037
Ali, I., Alam, S.D., Raja, R., Shirsath, V., Jain, A.K., Yusuf, K., Aljuwayid, A.M., Sillanpää, M. (2022). Chiral separation of β-blockers by supercritical fluid chromatography using Chiralpak-IG and Chiralpak IBN-5 columns. Chirality, 34(6), 848-855. https://doi.org/10.1002/chir.23440 DOI: https://doi.org/10.1002/chir.23440
Ali, I., Alam, S. D., Raja, R., Khan, S. A., Anjum, R., Jain, A. K., Locatelli, M. (2023). Advances in Simple and Chiral-HPLC Methods for Antiallergic Drugs and Chiral Recognition Mechanism. Analytica, 4(1), 66-83.). https://doi.org/10.3390/analytica4010007 DOI: https://doi.org/10.3390/analytica4010007
Asif, M., Yusuf, M., Almehmadi, Alsaiari, AA, Allahyani, M., Aljuaid M. and Alsharif, A (2024). Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica as Competent Natural Molecules to Treat COVID-19 Virus Variant. Letters in Organic Chemistry, 21(5), 466-477. https://doi.org/10.2174/0115701786263427231123103651 DOI: https://doi.org/10.2174/0115701786263427231123103651
da Costa, L. M., Oliveira de Almeida Leite, H., Kassab, N. M., & Singh, A. K. (2019). Green analytical methods for the separation of seven antihistamines: Application in separation of azelastine and related impurities in nasal solution. International Journal of Analytical Chemistry, 2019(9489723), 1-11. https://doi.org/10.1155/2019/9489723 DOI: https://doi.org/10.1155/2019/9489723
Hu, Y. P., Song, Y. R., Wang, D. F., Yang, Y. P., Hou, D. Y., & Ouyang, J. (2004). Study on enantiomeric separation of cetirizine on HPLC with a chiral ovomucoid column, Chinese Journal of Pharmaceutical Analysis, 24(3), 289–293.
Kang, S. W., Jang, H. J., Moore, V. S., Park, J. Y., Kim, K. A., Youm, J. R., & Han, S. B. (2010). Enantioselective determination of cetirizine in human plasma by normal-phase liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry. Journal of Chromatography B, 878(32), 3351-3357. https://doi.org/10.1016/j.jchromb.2010.10.019 DOI: https://doi.org/10.1016/j.jchromb.2010.10.019
Lim, C.K. and Lord, G. (2002). Current developments in LC-MS for Pharmaceutical Analysis, Biological & Pharmaceutical Bulletin, 25(5), 547–557. https://doi.org/10.1248/bpb.25.547 DOI: https://doi.org/10.1248/bpb.25.547
Raja, R., Alam, SD, Srisath, V., Jain, A.K., ALOthman, Z.A., Mohammed, A.AA. Mohammad, Islam, A., Bhatt, T. and Ali, I. (2021). A comparative study of chiral separation of proton pump inhibitors by supercritical fluid chromatography and high-performance liquid chromatography. Journal of Separation Science, 1–8. https://doi.org/10.1002/jssc.202100834 DOI: https://doi.org/10.1002/jssc.202100834
Shasho, H., Sakur, A.A. and Trefi, S. (2018). Separation and assay of four antihista-mine drugs diphenhydramine, chlorpheniramine, Cyproheptadine and Fexofenadine in pharmaceutical forms by a single HPLC method, International Journal of Pharmacy and Pharmaceutical Sciences, 10(4), 53-62. https://doi.org/10.22159/ijpps.2018v10i4.24819 DOI: https://doi.org/10.22159/ijpps.2018v10i4.24819
Simon, F.E. and Simons, K.J. (2008). H1 antihistamines: Current status and future directions, World Allergy Organization Journal, 1(9), 145–155. https://doi.org/10.1186/1939-4551-1-9-145 DOI: https://doi.org/10.1186/1939-4551-1-9-145
Tao, Q.F., Zhu, X.P. and Zhao, Y. (2007). Chiral resolution of cetirizine by capillary electrochromatography using norvancomycin hydrochloride as chiral selector,” Chinese Journal of Pharmaceutical Analysis, 27(5), pp. 686–688.
Xiong, X., Wang, K., Tang, T., Fang, J., & Chen, Y. (2021). Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers, Scientific Reports, 11(1), 1-18. https://doi.org/10.1038/s41598-021-87511-5 DOI: https://doi.org/10.1038/s41598-021-87511-5
Yusuf, M. (2023). Insights into the in-silico research: Current scenario, advantages, limits, and future perspectives. Life In Silico, 1(1), 13-25. https://life-insilico.com/index.php/pub/article/view/5
Zhou, J., Luo, P., Chen, S., Meng, L., Sun, C., Du, Q., & Sun, F. (2016). Enantioseparation of six antihistamines with immobilized cellulose chiral stationary phase by HPLC. Journal of chromatographic science, 54(4), 531-535. https://doi.org/10.1093/chromsci/bmv177 DOI: https://doi.org/10.1093/chromsci/bmv177
Published on: 25-04-2024
Also Available On
How to Cite
Issue
Section
License
Copyright (c) 2024 Shafat Ahmad Khan, Syed Dilshad Alam, Muralidhararao Bagadi, Rushda Anjum, Mohd Yusuf
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors contributing to this journal retain the copyright of their article but agree to publish their articles under the terms of the Creative Commons CC-BY 4.0 License (http://creativecommons.org/licenses/by/4.0/) allowing third parties to copy and redistribute the material in any medium or format, and to remix, transform, and build upon the material, for any purpose, even commercially, under the condition that appropriate credit is given, that a link to the license is provided, and that they indicate if changes were made. They may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
